Grant Funding

Active Grants:

2006-2017       R01 DK074656

Title:  mt-Nd2 and Resistance to Autoimmune Diabetes

Project Role:  Principal Investigator (40% Effort)

Source:  National Institutes of Health (NIDDK/NIAID)

Total Award:  $1,665,000 ($225,000/ year Direct)

Objective:  Understand the role that the C278A sequence variation in mt-Nd2 plays in resistance to T1D.

 

2010-2013       JDRF 25-2010-688

Title:  Islet Resistance to T1D (nPOD)

Project Role: Principal Investigator (5% Effort)

Source:  Juvenile Diabetes Foundation International

Total Award:  $110,000 ($50,000/ year Direct)

Objective:  Determine metabolic differences in the pancreatic islets comparing organs from individuals with T1D and those that have circulating autoantibodies to b cell antigens but do not have T1D.

 

2011-2014       ADA 1-11-BS-104

Title:  Idd22 controls resistance to autoimmune diabetes at the beta cell level

Project Role:  Principal Investigator (10% Effort)

Source:  American Diabetes Assocition (ADA)

Total Award:  $313,500 ($95,000/ year Direct)

Objective:  Identify Idd22 and the mechanism of b cell resistance.

 

2013-2015       JDRF 17-2012-595

Title:  Lymphocyte Mitochondrial Dysfunction in Type 1 Diabetes

Project Role:  Co-Principal Investigator (10% Effort)

Source:  Juvenile Diabetes Research Foundation (JDRF)

Total Award:  $495,000 ($150,000/ year Direct)

Objective:  Identify and determine novel lymphocyte mitochondrial biomarkers associated with Type 1 Diabetes

 

PENDING Support

R01AI103226-A1                                                                                   9/1/2013-8/31/2018

Source:  National Institutes of Health (NIDDK)

Title:  Divergent control of autoimmunity in T1D and SLE through the G-CSF pathway

Project Role:  Co-Investigator

Objective: This application will test the hypothesis that the G-CSF signaling pathway is critical to the pathogenesis of T1D and SLE and modulation of this pathway in opposite directions for the two autoimmune diseases will lead to disease prevention.

 

P01AI42288 (Atkinson, P.I.) Competitive Renewal                              9/01/13 – 08/31/18

Source:  National Institutes of Health NIAID

Title:  Immune Function and the Progression to Type I Diabetes

Role:  Co-Principal Investigator Project 2

Objective: To test our overall hypothesis that T1D results from a combination of genetic variants that negatively impact regulatory mechanisms, leading to a tissue-specific break in tolerance and islet b cell dysfunction and death

 

AN:3525662                                                                                          9/01/13 – 08/31/18

Source:  National Institutes of Health NIAID

Title:  Interferon a/b in Type 1 Diabetes Pathogenesis

Role: Principal Investigator (Multi-PI With Michael Clare-Salzler)

Objective:  To define the IFN  roles in regulating both acquired and innate responses associated with the pathology and immunogenetics of Type 1 Diabetes

 

Completed Support

2007-2010          JDRF 1-2007-77

Title:  Identification of Susp and the role of Susp in T1D-Resistance

Project Role: Principal Investigator (20% Effort)

Source:  Juvenile Diabetes Foundation International

Total Award:  $462,000 ($140,000/ year Direct)

Objective:  Define the T1D protective gene that is Susp, and examine the role of Susp in protection against T1D.

2003-2008          U19 AI056374

Title: Utilization of ALR Derived T1D Resistance Loci to Improve Islet Graft Outcome

Project Role:  Principal Investigator

Source:  National Institutes of Health (NIAID)

Total Award:  $1,480,000

Objective:  to determine if the heritable resistance of ALR islets to autoimmunity will extend to a defense against both allo-graft and auto-graft rejection

2000-2007          ERMS# 00035010 (PI:  Massimo Trucco)

Title:  New Advanced Technology to Improve Prediction and Prevention of Type 1 Diabetes

Project Role:  Co-Investigator

Source:  Department of Defense

Total Award:  $4,936,454 ($715,786/ year Direct)

Objective:  To utilize new technology, increasing the speed and relieving economic strain of genetic screening in large populations studies.

2007-2008          Smith and Nephew Diabetes Project (PI:  Jeffrey Hollinger, Carnegie Mellon University)

Title: Bone Wound Healing in the Akita model of type 1 Diabetes

Project Role:  Subcontract to Clayton E. Mathews

Source: Smith & Nephew Inc.

Direct Cost of Subcontract:  $50,000 Annual

Objective: Determine whether “bioactive molecule 1” and “bioactive molecule 2” enhance bone wound healing in the C57BL/6-Ins2Akita model of insulin requiring diabetes.

2006-2007          JDFI 5-2006-232

Title:  Generation of Cybrids to Study a mtDNA SNP Associated with T1D

Project Role:  Principal Investigator

Source:  Juvenile Diabetes Foundation International

Total Award:  $108,900 ($100,000/ year Direct)

Objective:  To generate and study cell lines with a polymorphism in the mitochondrial DNA polymorphism that is protective against Type 1 Diabetes.

2001-2006          JDFI 2-2001-860

Title: Genetics of Resistance to Immune-Mediated Beta Cell Destruction

Project Role:  Principal Investigator

Source:  Juvenile Diabetes Foundation International

Total Award:  $693,750 ($125,000/ year Direct)

Objective:  Fine map Insulin Dependant Diabetes resistance loci and elucidate the molecular basis for the unique resistance of ALR to immune-mediated injury

NOTE:  This grant was submitted for renewal July 14th, 2006.  Listed as #2 under the Pending Support Section.

1999-2001          NIH F32 DK09865

Title: Mechanisms of susceptibility to alloxan in mice

Project Role:  Principal Investigator

Source:  National Institutes of Health (NIDDK)

Total Award:  $201,600 ($40,000/ year Direct)

Objective:  Establish the genetic and biochemical basis for the differential susceptibility of ALR and ALS strains to chemically-induced diabetes.

1999-2002          ADA EHL, Inc.

Title: Molecular genetics of free radical defenses in alloxan resistant (ALR) mice

Project Role:  Co-Principal Investigator

Source:  American Diabetes Association

Total Award:  $333,000 ($100,000/ year Direct)

Objective:  Identify both the genetic map location and the function of the gene or genes conferring upon ALR/Lt mice such remarkable resistance to ROS damage.

1999-2001          JDF 1-1999-642

Title: Genetic up-regulation of free radical defenses to prevent IDDM in NOD mice

Project Role:  Co-Principal Investigator

Source:  Juvenile Diabetes Foundation International

Total Award:  $222,000 ($100,000/ year Direct)

Objective:  Examine the resistance of ALR islets to autoimmune effector mediated stress.