Jing Chen, PhD: Assistant Professor, Assistant Scientist

Assistant Scientist Office Address
UF Department of Pathology, Immunology and Laboratory Medicine
College of Medicine
1275 Center Drive
Biomedical Science Building J587
Gainesville, FL 32610

Administrative Support AST IEthan Maia de Needell

  • Phone: (352) 294-8493

Related Links

Primary Areas of Research

  • Genetics of Type 1 Diabetes
  • Interaction between genomic and mitochondrial genomes in the pathogenesis of Type 1 Diabetes
  • Role of mitochondrial function in pancreatic beta cells
  • Role of T-cell mitochondrial function during development of autoimmune Type 1 Diabetes


  • Chen J, Grieshaber S, Mathews CE (2011). Methods to assess beta cell death mediated by cytotoxic T lymphocytes. J Vis Exp. Jun 16;(52). pii: 2724. doi: 10.3791/2724.
  • Chen J, Gusdon AM, Mathews CE (2011). Role of genetics in resistance to type 1 diabetes.  Diabetes/Metabolism Research & Review.  Nov;27(8):849-53
  • Chen J, Gusdon AM, Piganelli JD, Leiter EH, Mathews CE (2011).  mt-Nd2a modifies resistance against autoimmune Type 1 diabetes in NOD mice at the level of the pancreatic beta cell. Diabetes. 60(1):355-9.
  • Lightfoot YL, Chen J, Mathews CE (2011).  Role of the Mitochondria in Immune-Mediated Apoptotic Death of the Human Pancreatic β Cell Line βLox5. PLoS One. 6(6):e20617. Epub 2011 Jun 27.
  • Gusdon AM, Chen J, Votyakova TV, Mathews CE (2009). Quantification, localization, and tissue specificities of mouse mitochondrial reactive oxygen species production. Methods Enzymol. 456:439-57.
  • Chen J, Gusdon AM, Thayer TC, Mathews CE (2008). Role of increased ROS dissipation in prevention of T1D: Lessons from the ALR mouse.  Ann N Y Acad Sci. Dec; 1150:157-66.
  • Chen J, Lu Y, Lee C-H, Li RH, Leiter EH, Mathews CE (2008). Comparative Genetics of Spontaneous Autoimmune versus Chemically-Induced Diabetes in Mice. Free Radic Biol Med. Nov 1;45(9):1263-70
  • Chen J, Hatori, Y, Nakajima K, Eizawa T, Ehara T, Koyama M, Hirai T, Fukuda Y, Kinoshita M, Suguyama A, Hayashi J-I, Onaya T, Kobayashi T, Tawata M (2006).  Mitochondrial complex I activity is significantly decreased in a patient with maternally inherited type 2 diabetes mellitus and hypertrophic cardiomyopathy associated with mitochondrial DNA C3310T mutation: a cybrid study.  Diabetes Res Clin Pract.  Nov;74(2):148-53
  • Chen J, Chen YG, Reifsnyder PC, Schott WH, Lee CH, Osborne M, Scheuplein F, Haag F, Koch-Nolte F, Serreze DV, Leiter EH (2006).  Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion. J Immunol. Apr 15;176(8):4590-9.
  • Chen J, Reifsnyder PC, Scheuplein F, Schott WH, Mileikovsky M, Soodeen-Karamath S, Nagy A, Dosch HM, Ellis J, Koch-Nolte F, Leitei EH (2005). “Agouti NOD”: Identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells” Mammalian Genome. Oct;16(10):775-83