Published Abstracts
1993 Mathews CE, Wickwire KL, Hathcock-Rice D, Berdanier CD. Effects of menhaden oil on maternal and growth diets of BHE/Cdb rats. FASEB J. 7:A820.
1995 Mathews CE, McGraw RA, Berdanier CD. A point mutation in the mitochondria DNA of diabetes-prone BHE/cdb rats. FASEB J. 9: A749.
1996 Mathews CE, Berdanier CD, Rose BS, Flatt WP. An indirect calorimetric study comparing BHE/cdb, Sprague Dawley and cross bred rats. FASEB J. 10: A745.
1998 Mathews CE, Langley SH, Leiter EH. Alloxan Induced IDDM in ALR & ALS Mice is Linked to Anti-Oxidant Defense Status. Diabetes. 47:A176.
1999 Mathews CE, Graser RT, Serreze DV, Leiter EH. ALR/Lt Mice: ß Cell Resistance to Chemical and Autoimmune Attack Associated with Increased Anti-oxidant Defenses. Diabetes. 48:A450.
1999 Mathews CE and Berdanier CD. Mitochondrial Mutations Decrease OXPHOS Capacity and ATP Production in NIDDM Prone BHE/Cdb Rats. Diabetes. 48:A451.
2000 Mathews CE, EA Johnson, EH Leiter. CTS/Shi mice: T-lymphocytopenia due to a lineage specific defect intrinsic to T cell precursors halting emigration of mature thymocytes. FASEB J. 14:A2151.
2000 Mathews CE, Graser RT, Johnson EA, Serreze DV, Leiter EH. Genetic Resistance to IDDM: A Role for ß Cell Expressed Resistance Determinants. Diabetes. 49:A70.
2001 Mathews CE, Bagley RJ, Caldwell JW, Leiter EH. NIDDM in a New Mouse Model Elicited by Low Free Radical Scavenging Potential Combined with Behavioral and Dietary Stress. Diabetes. 50:A78
2001 Mathews CE, Graser RT, Bagley RJ, Dunn BD, Caldwell JW, Serreze DV, Leiter EH. Genetic Similarities of Free Radical Dissipation and IDDM Resistance in ALR/Lt Mice. Diabetes 50:A517
2001 Bottino R, Tse H, Balamurugan AN, Mathews CE, Trucco M, Piganelli JD. Preservation of Human Islets after Isolation Using a Metalloporphyrin Based Superoxide Dismutase Mimic. Cell Transplantation 10:538
2001 Mathews CE, Langley SH, Leiter EH. New Mouse Model to Study Islet Transplantation in Insulin Dependent Diabetes Mellitus. Cell Transplantation 10:558
2002 Mathews CE, Bagley RJ, Holl T, Serreze DV & Leiter EH. Congenic analysis of H2gx-linked diabetes protection. Diabetes Metab Res Rev. 18(S4):S22.
2002 Mathews CE, Suarez-Pinzon W, Baust JJ, Rabinovitch A, Leiter EH. Mechanisms underlying resistance of ALR islets to cytokine destruction. Diabetes Metab Res Rev. 18(S4):S23.
2002 Mathews CE, Pietropaolo SL, Pietropaolo M. Reduced thymic DC expression of Islet antigen contributes to loss of self tolerance. Diabetes Metab Res Rev. 18(S4):S31.
2003 Chang Y, Yap S, Piganelli J, Bertera S, Giannokakis N, Mathews CE, Trucco M. The Combination of Autoantigen and Immune Regulatory Molecule DNA Vaccines Delays and Reduces T1DM in NOD mice. Diabetes. 52(S1):A66
2003 Mathews CE, Pietropaolo SL, Pietropaolo M. Reduced thymic DC expression of Islet antigen contributes to loss of self tolerance. Diabetes. 52(S1):A7
2004 Tse HM, Bauer L, Piganelli JD, Mathews CE. Genetic Ablation of NADPH Oxidase activity blocks T1D development in NOD mice. Diabetes. 53(S2):A26
2004 Mathews CE, Leiter EH, Spirina O, Bykhovskaya, Y, GusdonA, Fischel-Ghodsian N. Contribution of the Mitochondrial Genome in Resistance Against both Chemically-Induced Autoimmune Diabetes. Diabetes. 53(S2):A30
2004 Mathews CE, Votyakova T, Reynolds I. ALR/LtJ mtDNA Provides Protection from Oxidative Stress Induced Mitochondrial Dysfunction. Diabetes. 53(S2):A77
2005 Levesque MC, Mathews CE. Mutant Cat2 Protects ALR/LtJ Mouse Islets from Cytokine-Induced Beta Cell Destruction. Diabetes 54(S1):A77-A78.
2005 Olshansky G, Mathews CE. T1D Protective Locus Controls Increased Activity and Stability of Superoxide Dismutase 1. Diabetes 54(S1):A391
2005 Ge X, Rudert WA, Mathews CE, Piganelli JD, Trucco M. CD8+ Class I MHC H2Db-Restricted CTL Recognizes a GAD65 Peptide. Diabetes 54(S1):A309
2005 Chang Y, Mathews CE, Pietropaolo SL, Benos PV, Friday RP, Trucco M, Pietropaolo M. Promiscuous Gene Activation (PGA): Reduced Transcriptional Activity of Islet Autoantigen Contributes to Loss of Self-Tolerance. Diabetes. 54(S1):A94
2005 Gusdon AM, Olshansky G, Votyakova TV, Mathews CE. Novel mt-Nd2 Variant Encoded by the ALR/Lt Mouse Strain Provides Resistance to Free Radical-Induced Mitochondrial Dysfunction. Diabetes 54(S1):A81
2005 Ize-Ludlow D, Bottino R, Ellies L, Mathews CE. Solute Carrier Family 7 Member 2 (Slc7a2) Deficiency Alters First Phase Insulin Release (FPIR). Diabetes 54(S1)
2005 Wallet MA, Sen P, Mathews CE, Tisch R. MerTK is Required for Development of Type 1 Diabetes. Diabetes 54(S1)
2005 Park H-J, Zhang Y, Welzig CM, Du C, Aronovitz M, Georgescu SP, Mathews CE, Liao R, Blaustein RO, Karas RH, Galper JB. A Mouse Model for Diabetic Autonomic Neuropathy Demonstrates a Decrease in both Parasympathetic Response and Atrial Expression of GIRK1 (Kir3.1) J Am Heart Assoc.
2006 Gusdon AM, Votyakova TV, Mathews CE. The NADH Dehydrogenase 2 Subunit (mt-Nd2) Allele Encoded by the ALR/Lt Mouse Strain Protects Against T1D but Does Not Alter Basal Mitochondrial Function. Diabetes 55(S1):A42
2006 Ize-Ludlow D, Becker DJ, Mathews CE. Endocrine Abnormalities in NOD: a Dilemma of Controls. Diabetes 55(S1):A375
2006 Chen J, Leiter EH, Mathews CE. Diabetes Resistance at the ß Cell Level: Searching for Common ALR/Lt Genetic Protection Against Autoimmune and Free Radical-Induced Diabetes. Diabetes 55(S1):A42
2006 Tse HM, Mathews CE, Schreiner S, Milton MJ, Profozich J, Randa G, Piganelli JD. Redox Modulation Inhibits Diabetogenic T Cell Activation and T1D. Diabetes 55(S1):A89
2006 Park H, Zhang Y, Du C, Aronovitz M, Georgescu SP, Welzig CM, Mathews CE, Wang B, Liao R, Blaustein RO, Karas RH, Galper JB. SREBP1 Repairs the Parasympathetic Dysfunction in Atrial Myocytes from Diabetic Hearts. Circulation Research In Press
2007 Tse HM, Thayer TC, Mathews CE, Piganelli JD. Reactive Oxygen Species Generation Is Necessary For Autoimmune T Cell Effector Function. Diabetes 56(S1):A58
2007 Thayer TC, Tse HM, Steele C, Piganelli JD, Mathews CE. Critical Role of Superoxide Production in the Pathogenesis of Autoimmune Diabetes. Diabetes 56(S1):A59
2007 Chen J, Leiter, EH, Mathews CE. Susceptibility to Free Radical-Mediated and Autoimmune Diabetes is Controlled by Interactions of the Nuclear and Mitochondrial Genomes. Diabetes 56(S1):A64
2007 Kray A, Baust JJ, Vaidya S, Mathews CE, Hollinger JO. Defect Bone Health In Mice With The Akita Mutation In Ins2. Diabetes 56(S1):A196
2007 Mojaddidi MA, Al-Sunni AA, Goss J, Baust JJ, Mathews CE, Malik RA. Islet Cell Transplantation Prevents Myelinated Nerve Fibre Pathology In The C57BL/6-Ins2Akita Mouse. Diabetes 56(S1):A211
2007 Gusdon AM, Mathews CE. mt-Nd2a Protects Against T1D by Lowering Mitochondrial ROS Production. Diabetes 56(S1):A410
2007 Diego Ize-Ludlow, Bowman TA, Najjar SM, O’Doherty RM, Becker DJ, Mathews CE. Endocrine factors protect ALR mice from diabetes. Diabetes 56(S1):A675
2007 Votyakova TV, Chen J, Mathews CE. High sensitivity of beta cells to oxidative stress: monitoring mitochondrial (mt) function in live beta cells. Diabetes 56(S1):A686
2008 Chen J, Gusdon AM, Mathews CE. mt-Nd2a Protects a Beta Cell Line Against Immune- and Free Radical- Mediated Cell Death. Diabetes. 57(S1):A80
2008 Tse HM, Thayer TC, Mathews CE, Piganelli, JD. Reactive oxygen species generation is necessary for diabetogenic T cell effector function. Diabetes. 57(S1):A354
2008 Chen J, Mathews CE. Susceptibility to Free Radical-Mediated and Autoimmune Diabetes is Controlled by Retrogenetic Interactions of the Nuclear and Mitochondrial Genomes. Setting the Pace in Mitochondrial Medicine. Indianapolis, IN Jun 25-28
2008 Gusdon AM, Chen J, Mathews CE. mt-Nd2c Increases Susceptibility To Type 1 Diabetes By Increasing Mitochondrial Reactive Oxygen Species Production. Setting the Pace in Mitochondrial Medicine Conference. Setting the Pace in Mitochondrial Medicine. Indianapolis, IN Jun 25-28
2009 Chen J, Mathews CE. Susceptibility to Free Radical-Mediated and Autoimmune Diabetes is Controlled by Retrogenetic Interactions of the Nuclear and Mitochondrial Genomes. Diabetes. 58(S1):A16-A17
2009 Thayer TC, Campbell M, Pliner V, Mathews CE. Suppressor of superoxide production locus (Susp) increases Superoxide dismutase 1 (SOD1) stability and activity, resulting in altered neutrophil function and T1D resistance. Diabetes. 58(S1):A17
2009 Tse HM, Thayer T, Mathews CE, Piganelli JD. Inhibition of Superoxide Synthesis Prevents T Cell Autoreactivity. Diabetes. 58(S1):A50
2009 Ize-Ludlow D, Luzardo Y, Wasserfall C, Schatz D, Atkinson MA, Mathews CE. Progressive Erosion of Beta Cell Function Precedes the Onset of Type 1 Diabetes in the NOD Mouse. Diabetes. 58(S1):A327
2009 Luzardo Y, Chen J, Contreras J, Levine F, Mathews CE. Potential of blox5 Cell Line in Cell-Mediated Human Beta Cell Death Assays. Diabetes, In Press
2010 Campbell MS, Thayer TC, Liu C, Pliner V, Mathews CE. Suppressor of Superoxide Production Locus Dominantly Prevents T1D as Well as Insulitis and Maps to Ankrd50. Diabetes. 59(S1):A34
2010 Parker M, Wasserfall C, Xue S, Campbell-Thompson M, Mathews CE, Schatz D, Haller M, Atkinson M. Granulocyte Colony-Stimulating Factor Enhances Both ATG and Anti-CD3 mAb-Mediated Reversal of Type 1 Diabetes in NOD Mice. Diabetes. 59(S1):A117
2010 Chen J, Mathews CE. mt-Nd2a Allotype Provides on Type 1 Diabetes (T1D) Resistance at Both the Immune and β Cell Levels. Diabetes. 59(S1):A330
2010 Thayer TC, Delano MJ, Tse HM, Piganelli JD, Moldawer L, Mathews CE. Macrophage and T Cell ROS Production Is Critical for T1D Pathogenesis. Diabetes. 59(S1):A361
2010 Luzardo Y, Levine F, Mathews CE. Immune Mediators Kill the Human Beta Cell Line βlox5 by Apoptosis and Necrosis. Diabetes. 59(S1):A443
2012 Down Regulation of Glucokinase and Mitochondrial ATP Synthase in Islets from Type 1 Organ Donors. Lightfoot Y, Grieshaber S, Wilhem J, Zhang L, Campbell-Thompson M, Schatz D, Atkinson MA, Mathews CE. nPOD Annual Meeting, Miami, FL
2012 Ojiaku CA, Annamalai M, Liu C, Chen J, Caldwell JW, Mathews CE. NADPH Oxidase 2 is Not Essential for Optimal Glucose Stimulated Insulin Secretion. Diabetes. In Press.
2012 Lightfoot YL, Chen J, Mathews CE. mt-ND2a Protects Human β Cells from Immune-Mediated Destruction. Diabetes. In Press
2012 Liu C, Thayer TC, Mathews CE. Suppressor of superoxide production (Susp) protects NOD mice against type 1 diabetes through modulation of superoxide dismutase 1. Immunology of Diabetes Society Annual Meeting, Victoria, Canada, June, 2012
2012 Chen J, Knapp S, Li J, Zhang S, Leon L, Annamalai M, Mathews CE. Idd22 protects against autoimmune diabetes by preventing T cell trafficking to target beta cells. Immunology of Diabetes Society Annual Meeting, Victoria, Canada, June, 2012
2012 Lightfoot YL, Chen J, Mathews CE. mt-Nd2a protects human and mouse beta cells against immune-mediated cell death. Immunology of Diabetes Society Annual Meeting, Victoria, Canada, June, 2012
2012 Lightfoot YL, Vendrame F, Grieshaber SS, Wilhem J, Campbell-Thompson M, Schatz DA, Atkinson MA, Burke G, Pugliese A, Mathews CE. Markers of Beta Cell Dysfunction and Inflammation Persist in Subjects with Established Type 1 Diabetes. Federation of Clinical Immunologists Society (FOCiS) 2012 Conference. Vancouver, Canada, June, 2012
2012 Li J, Cassidy R, Welch D, Mathews CE, Chen J. Mitochondria in T Cells of Type 1 Diabetic patients and at risk individuals exhibit inner membrane hyperpolarization. Federation of Clinical Immunologists Society (FOCiS) 2012 Conference. Vancouver, Canada, June, 2012
2012 Liu C & Mathews CE. Indispensable Role of NADPH Oxidase in Cytotoxic T Cell Responses:
Consequences for Type 1 Diabetes. Federation of Clinical Immunologists Society (FOCiS) 2012 Conference. Vancouver, Canada, June, 2012