Published Abstracts

1993    Mathews CE, Wickwire KL, Hathcock-Rice D, Berdanier CD.  Effects of menhaden oil on maternal and growth diets of BHE/Cdb rats.  FASEB J.  7:A820.

1995    Mathews CE, McGraw RA, Berdanier CD.  A point mutation in the mitochondria DNA of diabetes-prone BHE/cdb rats.  FASEB J.  9: A749.

1996    Mathews CE, Berdanier CD, Rose BS, Flatt WP.  An indirect calorimetric study comparing BHE/cdb, Sprague Dawley and cross bred rats.  FASEB J.  10: A745.

1998    Mathews CE, Langley SH, Leiter EH.  Alloxan Induced IDDM in ALR & ALS Mice is Linked to Anti-Oxidant Defense Status.  Diabetes.  47:A176.

1999    Mathews CE, Graser RT, Serreze DV, Leiter EH.  ALR/Lt Mice: ß Cell Resistance to Chemical and Autoimmune Attack Associated with Increased Anti-oxidant Defenses.  Diabetes.  48:A450.

1999    Mathews CE and Berdanier CD.  Mitochondrial Mutations Decrease OXPHOS Capacity and ATP Production in NIDDM Prone BHE/Cdb Rats.  Diabetes.  48:A451.

2000    Mathews CE, EA Johnson, EH Leiter.  CTS/Shi mice: T-lymphocytopenia due to a lineage specific defect intrinsic to T cell precursors halting emigration of mature thymocytes.  FASEB J.  14:A2151.

2000    Mathews CE, Graser RT, Johnson EA, Serreze DV, Leiter EH.  Genetic Resistance to IDDM: A Role for ß Cell Expressed Resistance Determinants.  Diabetes.  49:A70.

2001    Mathews CE, Bagley RJ, Caldwell JW, Leiter EH.  NIDDM in a New Mouse Model Elicited by Low Free Radical Scavenging Potential Combined with Behavioral and Dietary Stress.  Diabetes.  50:A78

2001    Mathews CE, Graser RT, Bagley RJ, Dunn BD, Caldwell JW, Serreze DV, Leiter EH.  Genetic Similarities of Free Radical Dissipation and IDDM Resistance in ALR/Lt Mice.  Diabetes  50:A517

2001    Bottino R, Tse H, Balamurugan AN, Mathews CE, Trucco M, Piganelli JD.  Preservation of Human Islets after Isolation Using a Metalloporphyrin Based Superoxide Dismutase Mimic.  Cell Transplantation 10:538

2001    Mathews CE, Langley SH, Leiter EH.  New Mouse Model to Study Islet Transplantation in Insulin Dependent Diabetes Mellitus.  Cell Transplantation 10:558

2002    Mathews CE, Bagley RJ, Holl T, Serreze DV & Leiter EH.  Congenic analysis of H2gx-linked diabetes protection.  Diabetes Metab Res Rev.  18(S4):S22.

2002    Mathews CE, Suarez-Pinzon W, Baust JJ, Rabinovitch A, Leiter EH.   Mechanisms underlying resistance of ALR islets to cytokine destruction.  Diabetes Metab Res Rev.  18(S4):S23.

2002    Mathews CE, Pietropaolo SL, Pietropaolo M.  Reduced thymic DC expression of Islet antigen contributes to loss of self tolerance.  Diabetes Metab Res Rev.  18(S4):S31.

2003    Chang Y, Yap S, Piganelli J, Bertera S, Giannokakis N, Mathews CE, Trucco M.  The Combination of Autoantigen and Immune Regulatory Molecule DNA Vaccines Delays and Reduces T1DM in NOD mice.  Diabetes.  52(S1):A66

2003    Mathews CE, Pietropaolo SL, Pietropaolo M.  Reduced thymic DC expression of Islet antigen contributes to loss of self tolerance.  Diabetes.  52(S1):A7

2004    Tse HM, Bauer L, Piganelli JD, Mathews CE.  Genetic Ablation of NADPH Oxidase activity blocks T1D development in NOD mice.  Diabetes.  53(S2):A26

2004    Mathews CE, Leiter EH, Spirina O, Bykhovskaya, Y, GusdonA, Fischel-Ghodsian N.  Contribution of the Mitochondrial Genome in Resistance Against both Chemically-Induced Autoimmune Diabetes.  Diabetes.  53(S2):A30

2004    Mathews CE, Votyakova T, Reynolds I.  ALR/LtJ mtDNA Provides Protection from Oxidative Stress Induced Mitochondrial Dysfunction.  Diabetes.  53(S2):A77

2005    Levesque MC, Mathews CE.  Mutant Cat2 Protects ALR/LtJ Mouse Islets from Cytokine-Induced Beta Cell Destruction.  Diabetes 54(S1):A77-A78.

2005    Olshansky G, Mathews CE.  T1D Protective Locus Controls Increased Activity and Stability of Superoxide Dismutase 1.  Diabetes  54(S1):A391

2005    Ge X, Rudert WA, Mathews CE, Piganelli JD, Trucco M.  CD8+ Class I MHC H2Db-Restricted CTL Recognizes a GAD65 Peptide.  Diabetes  54(S1):A309

2005    Chang Y, Mathews CE, Pietropaolo SL, Benos PV, Friday RP, Trucco M, Pietropaolo M.  Promiscuous Gene Activation (PGA): Reduced Transcriptional Activity of Islet Autoantigen Contributes to Loss of Self-Tolerance.  Diabetes.  54(S1):A94

2005    Gusdon AM, Olshansky G, Votyakova TV, Mathews CE.  Novel mt-Nd2 Variant Encoded by the ALR/Lt Mouse Strain Provides Resistance to Free Radical-Induced Mitochondrial Dysfunction.  Diabetes  54(S1):A81

2005    Ize-Ludlow D, Bottino R, Ellies L, Mathews CE.  Solute Carrier Family 7 Member 2 (Slc7a2) Deficiency Alters First Phase Insulin Release (FPIR).  Diabetes  54(S1)

2005    Wallet MA, Sen P, Mathews CE, Tisch R.  MerTK is Required for Development of Type 1 Diabetes.  Diabetes  54(S1)

2005    Park H-J, Zhang Y, Welzig CM, Du C, Aronovitz M, Georgescu SP, Mathews CE, Liao R, Blaustein RO, Karas RH, Galper JB.  A Mouse Model for Diabetic Autonomic Neuropathy Demonstrates a Decrease in both Parasympathetic Response and Atrial Expression of GIRK1 (Kir3.1)  J Am Heart Assoc.

2006    Gusdon AM, Votyakova TV, Mathews CE.  The NADH Dehydrogenase 2 Subunit (mt-Nd2) Allele Encoded by the ALR/Lt Mouse Strain Protects Against T1D but Does Not Alter Basal Mitochondrial Function.  Diabetes  55(S1):A42

2006    Ize-Ludlow D, Becker DJ, Mathews CE.  Endocrine Abnormalities in NOD: a Dilemma of Controls.  Diabetes  55(S1):A375

2006    Chen J, Leiter EH, Mathews CE.  Diabetes Resistance at the ß Cell Level: Searching for Common ALR/Lt Genetic Protection Against Autoimmune and Free Radical-Induced Diabetes.  Diabetes  55(S1):A42

2006    Tse HM, Mathews CE, Schreiner S, Milton MJ, Profozich J, Randa G, Piganelli JD.  Redox Modulation Inhibits Diabetogenic T Cell Activation and T1D.  Diabetes  55(S1):A89

2006    Park H, Zhang Y, Du C, Aronovitz M, Georgescu SP, Welzig CM, Mathews CE, Wang B, Liao R, Blaustein RO, Karas RH, Galper JB.  SREBP1 Repairs the Parasympathetic Dysfunction in Atrial Myocytes from Diabetic Hearts.  Circulation Research  In Press

2007    Tse HM, Thayer TC, Mathews CE, Piganelli JD.  Reactive Oxygen Species Generation Is Necessary For Autoimmune T Cell Effector Function. Diabetes  56(S1):A58

2007    Thayer TC, Tse HM, Steele C, Piganelli JD, Mathews CE. Critical Role of Superoxide Production in the Pathogenesis of Autoimmune Diabetes.  Diabetes  56(S1):A59

2007    Chen J, Leiter, EH, Mathews CE. Susceptibility to Free Radical-Mediated and Autoimmune Diabetes is Controlled by Interactions of the Nuclear and Mitochondrial Genomes.  Diabetes 56(S1):A64

2007    Kray A, Baust JJ, Vaidya S, Mathews CE, Hollinger JO.  Defect Bone Health In Mice With The Akita Mutation In Ins2.  Diabetes  56(S1):A196

2007    Mojaddidi MA, Al-Sunni AA, Goss J, Baust JJ, Mathews CE, Malik RA.  Islet Cell Transplantation Prevents Myelinated Nerve Fibre Pathology In The C57BL/6-Ins2Akita Mouse.  Diabetes 56(S1):A211

2007    Gusdon AM, Mathews CE.  mt-Nd2a Protects Against T1D by Lowering Mitochondrial ROS Production.  Diabetes  56(S1):A410

2007    Diego Ize-Ludlow, Bowman TA, Najjar SM, O’Doherty RM, Becker DJ, Mathews CE.  Endocrine factors protect ALR mice from diabetes.  Diabetes  56(S1):A675

2007    Votyakova TV, Chen J, Mathews CE. High sensitivity of beta cells to oxidative stress:  monitoring mitochondrial (mt) function in live beta cells.  Diabetes  56(S1):A686

2008    Chen J, Gusdon AM, Mathews CE.  mt-Nd2a Protects a Beta Cell Line Against Immune- and Free Radical- Mediated Cell Death.  Diabetes.  57(S1):A80

2008    Tse HM, Thayer TC, Mathews CE, Piganelli, JD.  Reactive oxygen species generation is necessary for diabetogenic T cell effector function.  Diabetes.  57(S1):A354

2008    Chen J, Mathews CE.  Susceptibility to Free Radical-Mediated and Autoimmune Diabetes is Controlled by Retrogenetic Interactions of the Nuclear and Mitochondrial Genomes.  Setting the Pace in Mitochondrial Medicine.  Indianapolis, IN Jun 25-28

2008    Gusdon AM, Chen J, Mathews CE.  mt-Nd2c Increases Susceptibility To Type 1 Diabetes By Increasing Mitochondrial Reactive Oxygen Species Production.  Setting the Pace in Mitochondrial Medicine Conference.  Setting the Pace in Mitochondrial Medicine.  Indianapolis, IN Jun 25-28

2009    Chen J, Mathews CE.  Susceptibility to Free Radical-Mediated and Autoimmune Diabetes is Controlled by Retrogenetic Interactions of the Nuclear and Mitochondrial Genomes.  Diabetes.  58(S1):A16-A17

2009    Thayer TC, Campbell M, Pliner V, Mathews CE.  Suppressor of superoxide production locus (Susp) increases Superoxide dismutase 1 (SOD1) stability and activity, resulting in altered neutrophil function and T1D resistance.  Diabetes.  58(S1):A17

2009    Tse HM, Thayer T, Mathews CE, Piganelli JD.  Inhibition of Superoxide Synthesis Prevents T Cell Autoreactivity.  Diabetes.  58(S1):A50

2009    Ize-Ludlow D, Luzardo Y, Wasserfall C, Schatz D, Atkinson MA, Mathews CE.  Progressive Erosion of Beta Cell Function Precedes the Onset of Type 1 Diabetes in the NOD Mouse.  Diabetes.  58(S1):A327

2009    Luzardo Y, Chen J, Contreras J, Levine F, Mathews CE.  Potential of blox5 Cell Line in Cell-Mediated Human Beta Cell Death Assays. Diabetes, In Press

2010    Campbell MS,  Thayer TC, Liu C, Pliner V, Mathews CE.  Suppressor of Superoxide Production  Locus Dominantly Prevents T1D as Well as Insulitis and Maps to Ankrd50.  Diabetes.  59(S1):A34

2010    Parker M, Wasserfall C, Xue S, Campbell-Thompson M, Mathews CE, Schatz D, Haller M, Atkinson M. Granulocyte Colony-Stimulating Factor Enhances Both ATG and Anti-CD3 mAb-Mediated Reversal of Type 1 Diabetes in NOD Mice.  Diabetes.  59(S1):A117

2010    Chen J, Mathews CE.  mt-Nd2a Allotype Provides on Type 1 Diabetes (T1D) Resistance at Both the Immune and β Cell Levels.  Diabetes.  59(S1):A330

2010    Thayer TC, Delano MJ, Tse HM, Piganelli JD, Moldawer L, Mathews CE.  Macrophage and T Cell ROS Production Is Critical for T1D Pathogenesis.  Diabetes.  59(S1):A361

2010    Luzardo Y, Levine F, Mathews CE.  Immune Mediators Kill the Human Beta Cell Line βlox5 by Apoptosis and Necrosis.  Diabetes.  59(S1):A443

2012    Down Regulation of Glucokinase and Mitochondrial ATP Synthase in Islets from Type 1 Organ Donors.  Lightfoot Y, Grieshaber S, Wilhem J, Zhang L, Campbell-Thompson M, Schatz D, Atkinson MA, Mathews CE.  nPOD Annual Meeting, Miami, FL

2012    Ojiaku CA, Annamalai M, Liu C, Chen J, Caldwell JW, Mathews CE.  NADPH Oxidase 2 is Not Essential for Optimal Glucose Stimulated Insulin Secretion.  Diabetes.  In Press.

2012    Lightfoot YL, Chen J, Mathews CE.  mt-ND2a Protects Human β Cells from Immune-Mediated Destruction.  Diabetes.  In Press

2012    Liu C, Thayer TC, Mathews CE.  Suppressor of superoxide production (Susp) protects NOD mice against type 1 diabetes through modulation of superoxide dismutase 1.  Immunology of Diabetes Society Annual Meeting, Victoria, Canada, June, 2012

2012    Chen J, Knapp S, Li J, Zhang S, Leon L, Annamalai M, Mathews CE.  Idd22 protects against autoimmune diabetes by preventing T cell trafficking to target beta cells.  Immunology of Diabetes Society Annual Meeting, Victoria, Canada, June, 2012

2012    Lightfoot YL, Chen J, Mathews CE.  mt-Nd2a protects human and mouse beta cells against immune-mediated cell death.  Immunology of Diabetes Society Annual Meeting, Victoria, Canada, June, 2012

2012    Lightfoot YL, Vendrame F, Grieshaber SS, Wilhem J, Campbell-Thompson M, Schatz DA, Atkinson MA, Burke G, Pugliese A, Mathews CE.  Markers of Beta Cell Dysfunction and Inflammation Persist in Subjects with Established Type 1 Diabetes.  Federation of Clinical Immunologists Society (FOCiS)  2012 Conference.  Vancouver, Canada, June, 2012

2012    Li J, Cassidy R, Welch D, Mathews CE, Chen J.  Mitochondria in T Cells of Type 1 Diabetic patients and at risk individuals exhibit inner membrane hyperpolarization.  Federation of Clinical Immunologists Society (FOCiS)  2012 Conference.  Vancouver, Canada, June, 2012

2012    Liu C & Mathews CE.  Indispensable Role of NADPH Oxidase in Cytotoxic T Cell Responses:
Consequences for Type 1 Diabetes.  Federation of Clinical Immunologists Society (FOCiS)  2012 Conference.  Vancouver, Canada, June, 2012