Invited Lectureships

1997

1.         Role of mitochondrial mutations in inherited metabolic diseases

The Jackson Laboratory, Bar Harbor, ME.  September 30^th, 1997

2.         Inheritance of NIDDM in the BHE/Cdb Rat

The Jackson Laboratory, Bar Harbor, ME.  November 11, 1997

1998

1.         Molecular Characterization of the MHC region of ALR and ALS Mice

New England Immunology Society, Woods Hole, MA.  Spetember 23, 1998

2.         Genetics of Resistance to Alloxan Induced Diabetes

The Jackson Laboratory, Bar Harbor, ME.  November 4^th, 1998

1999

1.         Importance of ICR Derived Mouse Strains for Diabetes Research

The Jackson Laboratory, Bar Harbor, ME.  April 23^rd, 1999

2.         ALR/Lt Islets Are Remarkably Resistant To Cytokine and Autoimmune Attack

4^th Immunology of Diabetes Society, November 15^th,1999

2000

1.         Why Can’t CTS Get an Invitation to the Thymocyte Debutante Ball?

The Jackson Laboratory, Bar Harbor, ME.  February 4^th, 2000

2.         Is it Fate?  Can Beta Cells Control Their Own Destiny In Autoimmune Diabetes?

The Jackson Labroatory, Bar Harbor, ME.  April, 28^th, 2000

3.         Does the ß cell play a part in autoimmune diabetes or is it the corpse at a funeral?

Corixa Corporation, Palo Alto, CA.  May 10, 2000

4.         CTS/Shi mice: T-lymphocytopenia due to a lineage specific defect intrinsic to T cell precursors halting emigration of mature thymocytes

American Association of Immunologists Annual Meeting, Seattle, WA.  May 15, 2000

5.         Genetic Resistance to IDDM: A Role for ß-Cell Expressed Resistance Determinants

American Diabetes Association Scientific Sessions, June 5^th, 2000

6.         Does the ß cell play a part in autoimmune diabetes or is it the corpse at a funeral?

Children’s Hospital of Pittsburgh, Pittsburgh, PA.  August 29, 2000

7.         Free Radical Scavenging Potential in New Mouse Models of Diabetes Susceptibility and Resistance

Roche Symposium for Animals Models of NIDDM, September 19^th, 2000

8.         Dissipation is a Good Thing!  Genetic Similarities of IDDM Resistance & Free Radical Dissipation in ALR/Lt Mice

The Jackson Laboratory, Bar Harbor, ME.  December 12^th, 2000

2001

1.         Heightened Free Radical Dissipation Ability in a Diabetes-Resistant Mouse Strain

Biochemistry Department, University of Maine, Orono, ME.  February 2, 2001.

2.         The Alloxan Susceptible Mouse Strain:  A New Model for the Study of T2DM

The Jackson Laboratory Post-Doctoral Symposium, March 13, 2001

3.         Can Anti-oxidants Dissipate Autoimmune Diabetes? Genetic Similarities of IDDM Resistance &  Free Radical Dissipation in ALR/Lt Mice

Molecular Genetics and Biochemistry Department, University of Pittsburgh Medical Center, April 22, 2001

4.         Genetic Similarities of Free Radical Dissipation and IDDM Resistance in ALR/Lt Mice.

American Diabetes Association Scientific Sessions, June 19, 2001

5.         New Mouse Model to Study Islet Transplantation in Insulin Dependent Diabetes Mellitus

Cell Transplant Society, 10^th Congress, Keystone, CO.  October 17^th, 2001

6.         Animal Models for the Study of Autoimmune Diabetes and Islet Transplantation

Children’s Hospital of Pittsburgh, Pittsburgh, PA.  December 12, 2001

2002

1.         Genetic Control of Thymocyte Emigration

Children’s Hospital of Pittsburgh, Pittsburgh, PA.  February 19, 2002

2.         Dietary Components Can Regulate the Penetrance of Autoimmune Diabetes Susceptibility

University of Pittsburgh School of Medicine, University Wide Endocrine Conference, March 28, 2002

3.         What Controls End Stage T cell Development?  Genetic Analysis of Peripherial T cell Deficiency in the CTS Mouse Strain.

Rocky Mountain Labs, Hamilton, MT, August 1^st, 2002

4.         Mechanisms Underlying Resistance Of ALR Islets To Cytokine Destruction

Immunology of Diabetes Society, Copper Mountain, CO.  September 22, 2002

5.         Reduced Thymic DC Expression of Islet Cell Antigen 69 Contributes to Loss of Self Tolerance

Immunology of Diabetes Society, Copper Mountain, CO.  September 23, 2002

6.         Congenic Analysis of H2^gx-Linked T1D-Protection

Immunology of Diabetes Society, Copper Mountain, CO.  September 24, 2002

7.         Thymic Education:  What Governs the Change from Thymocyte to T cell?

University of Pittsburgh, School of Medicine Immunology Department, October 31^st, 2002

8.         Maternal Influence on Resistance to Alloxan-Induced Diabetes

Children’s Hospital of Pittsburgh Diabetes Institute Seminar, Pittsburgh, PA.  November 18^th, 2002

2003

1.         Enemies at the Gate:  Genetic Resistance at the Pancreatic Islet level in Autoimmune Diabetes

Children’s Hospital of Pittsburgh Molecular Medicine Research Seminar, January 9^th, 2003

2.         Lack of Free Radical Scavenging Potential is linked to Diabetes Susceptibility

International Group on Insulin Secretion, March 18th, 2003

3.         Disarming the Immune System, Subversive Propaganda, or Molecular Shielding:  How do ALR Pancreatic Islets Avoid Autoimmune Destruction?

University of Massachusetts Medical Center, Worchester, MA.  April 28^th, 2003

4.         Debutantes Need the Right Genetics:  A locus that Controls Thymocyte Emigration

Merck and Company, Rahway, NJ.  May 21^st, 2003

5.         Association of Monocyte Free Radical Production and Autoimmune Diabetes

Children’s Hospital of Pittsburgh Diabetes Institute Seminar, Pittsburgh, PA.  May 21^st, 2003

6.         Novel Variant of mt-Nd2 Provides Protection Against Autoimmune Diabetes

Children’s Hospital of Pittsburgh Diabetes Institute Seminar, Pittsburgh, PA.  June 1^st, 2003

7.         Reduced Thymic DC Expression of Islet Cell Antigen 69 Contributes to Loss of Self Tolerance

American Diabetes Association Scientific Sessions, New Orleans, LA, June 11^th, 2003

8.         ALS/Lt:  A New Mouse Model of Diabetes Susceptibility Associated with Low Free Radical Scavenging Potential

Lessons From Animal Models of Diabetes, 9^th Congress, Bar harbor, ME.  June 15th, 2003

2004

1.         Beta Cell Murder or Suicide: Does Autoimmunity Kill beta cells by Necrotic or Apoptotic Mechanisms in T1D

Children’s Hospital of Pittsburgh Diabetes Institute Seminar, Pittsburgh, PA.  march 16^th, 2004

2.         Failure of NF-kB Activity in ALR Islets and Resistance to Autoimmunity

St. Louis University Biochemistry Department, St. Louis, MO, April 21^st, 2004

3.         A Steel Curtain for Beta Cells.  Improved Defenses inhibit Autoimmune Killing of ALR Islets.

University of Pittsburgh, School of Medicine Immunology Department, May 24^th, 2004

4.         Contribution of the Mitochondrial Genome to Resistance Against both Chemically-Induced and Autoimmune Diabetes

American Diabetes Association Scientific Sessions, Orlando, FL.  June 5^th, 2004

5.         What Failure Makes the Beta Cell Fail in Type 1 Diabetes?  Failure in Self Defense.

American Diabetes Association Scientific Sessions, Orlando, FL.  June 5^th, 2004

6.         Mitochondrial Sequence Variation Provides Protection from Oxidative Stress Induced Mitochondrial Dysfunction

American Diabetes Association Scientific Sessions, Orlando, FL.  June 8^th, 2004

7.         A Single Nucleotide Polymorphism in the Mitochondrial Gene for NADPH Dehydrogenase Subunit 2 Contributes Resistance to Autoimmune Diabetes

United Mitochondrial Disease Foundation Annual Meeting, Pittsburgh, PA. August 6^th, 2004

8.         Association of Diabetes with Genetic Variation in the Mitochondrial Genome in Mice and Man

University of Pittsburgh Medical Center, University Wide Clinical Endocrinology Conference October 1^st, 2004

2005

1.         Genetics of T1D in Animal Models: 20 Years Later

Children’s Hospital of Pittsburgh, Diabetes Institute Seminar Series, February 16th, 2005

2.         Novel mt-Nd2 Variant Encoded by the ALR/Lt Mouse Strain Provides Resistance to Free Radical-Induced Mitochondrial Dysfunction

International Group on Insulin Secretion.  Nice, France. March 10^th, 2005

3.         Genetics of resistance to immune mediated beta-cell destruction.

Juvenile Diabetes Research Foundation Fellows Conference.  Chantilly, VA, March 24^th, 2005

4.         Animal Models for the Study of Diabetes

Pediatric Endocrinology Fellows Conference.  Pittsburgh, PA.  May 5^th, 2005.

5.         Mutant Cat2 Protects ALR/LtJ Mouse Islets from Cytokine-Induced Beta Cell Destruction.  American Diabetes Association Scientific Sessions, San Diego, CA.  June 13^th, 2005

6.         Islet Insubordination:  ALR/LtJ Genes Bestow a Failure to Comply with Autoimmune Stimuli

The Jackson Laboratory, November 10^th, 2005

7.         Development of Diabetes Complications in diabetic C57BL/6-Ins2^Akita Mice

The Jackson Laboratory, November 11^th, 2005

2006

1.         New Insights into Thymocyte Emigration.

Albert Einstein College of Medicine Research Seminar Series, April 3, 2006

2.         Islet Insubordination:  ALR/LtJ Genes Bestow a Failure to Comply with Autoimmune Stimuli

Children’s Hospital of Pittsburgh Molecular Medicine Research Seminar, June 27^th, 2006

3.         Positional Cloning of a Locus Controls Thymocyte Emigration

University of Pittsburgh, School of Medicine Immunology Department, July 6^th, 2006

4.         A Steel Curtain for Beta Cells.  Improved Defenses Inhibit Autoimmune Killing of ALR Islets.

University of Michigan, Department of Medicine, July 12^th, 2006

5.         Global Resistance to Inflammation Results in Resistance to Both Type 1 and Type 2 Diabetes.

University of Pittsburgh, School of Medicine, Metabolism Interest Group, August 23^rd, 2006

6.         Resistance to Autoimmune Diabetes at the Beta Cell Level:  Tales from the ALR Mouse.

University of Florida, Department of Pathology, November 15, 2006

7.         Toxin Resistance Yields Clues for Resistance to Autoimmune Diabetes.

University of Pittsburgh, Department of Environmental and Occupational Health, December 7, 2006.

2007

1.         Nuclear-Mitochondrial Interactions Affect Electron Transport Chain ROS production.

Children’s Hospital of Pittsburgh, Diabetes Institute Seminar Series, Pittsburgh, PA , February 16th, 2005

2.         Solute Carrier Family 7 Member 2 (Slc7a2) is critical for Arginine-Stimulated Insulin Release.  International Group on Insulin Secretion.  Nice, France. March 10^th, 2007

3.         Genetics of Mitochondrial Contribution to Beta Cell Susceptibility to Autoimmune-Mediated Destruction.  American Diabetes Association Annual Scientific Sessions, Chicago, IL.  June 24, 2007

4.         Benign Symbiotes or Rebellious Subjugates: Novel Roles for Proteins Encoded by the Mitochondrial Genome.  Symposium for the Use of Animal Models for Understanding the Pathogenesis of Diabetes, Boston, MA.  July 26, 2007

5.         Inbred strain variations in glucose tolerance and resistance to metabolic stress.  Discovery Strategies Conference: Modeling Human Metabolic Syndrome and Type 2 Diabetes in Rodents, Bar Harbor, ME.  August 6, 2007

2008

1.         Role of mitochondria in autoimmune-mediated destruction of beta cells.

8th Annual Rachmiel Levine Symposium, Translational Research in Type 1 Diabetes: Beyond Insulin and the Edmonton Protocol, Newport Beach, CA.  January 13, 2008

2.         New models to test old hypotheses in mitochondrial biology

University of Florida, Mitochondrial Interest Group, June 11, 2009

3.         Genetic variation in the mitochondrial genome & diabetes

Department of Food Science and Human Nutrition, University of Florida, October 9, 2009

4.         mt-Nd2 and Resistance to Autoimmune Diabetes

National Institutes of Health, NIDDK, November 17, 2009

2009

1.         Prevention of T1D by blocking beta cell death: Lessons from the ALR mouse.

Department of Pathology, Immunology, and Laboratory Medicine, work in progress seminar series, January 5, 2009.

2.         Susceptibility to spontaneous autoimmune and free radical-mediated diabetes is controlled by interactions of the nuclear & mitochondrial genomes

The Burnham Institute, Orlando, FL.  February 13, 2009

3.         Prevention of Beta Cell Destruction Prior to and After Onset of Type 1 Diabetes

Grand Rounds, Department of Pathology, Immunology, and Laboratory Medicine, University of Florida

4.         Superoxide Alters the Texture of Inflammation

University of Alabama, Birmingham, AL, September 17, 2009

5.         Intergenomic Interactions between the Nuclear & Mitochondrial Genomes Control Susceptibility to Diabetes

LSU Health Sciences Center, Shreveport, LA, October 8, 2009

2010

1.         A Little Dissipation is a Good Thing

University of South Alabama, Mobile, AL, January 2010

2.         Diabetes Research in the Swamp

The Jackson Laboratory, Bar Harbor, ME, August 16, 2010

2011

1.         Dissipating Autoimmunity:  Role of Reactive Oxygen Species in Adaptive Immune Effector Function

Rheumatology, work in progress seminar series, University of Florida, January 5, 2011.

2.         Mitochondria, Oxidants, Beta Cells, and Diabetes

Experimental Biology, Washington, DC, April 12, 2011

3.         Beta Cell Dysfunction and Type 1 Diabetes

Endocrinology Conference, University of Florida, July 19, 2011

4.         Autoimmune Diabetes

HHMI Seminar Series, University of Florida, September 20, 2011

5.         Personalization of Immunotherapy for Type 1 Diabetes Using Metabolic Markers

Program in Personalized & Genomic Medicine Seminar Series, University of Maryland School of Medicine, November 9, 2011

2012

1.         New developments in beta cell participation in type 1 diabetes

Diabetes Care Program, Gainesville, FL, January 20, 2012

2.         Wassup in type 1 diabetes research

Department of Pathology, Immunology, and Laboratory Medicine, work in progress seminar series, January 5, 2012.