Invited Lectureships
1997
1. Role of mitochondrial mutations in inherited metabolic diseases
The Jackson Laboratory, Bar Harbor, ME. September 30th, 1997
2. Inheritance of NIDDM in the BHE/Cdb Rat
The Jackson Laboratory, Bar Harbor, ME. November 11, 1997
1998
1. Molecular Characterization of the MHC region of ALR and ALS Mice
New England Immunology Society, Woods Hole, MA. Spetember 23, 1998
2. Genetics of Resistance to Alloxan Induced Diabetes
The Jackson Laboratory, Bar Harbor, ME. November 4th, 1998
1999
1. Importance of ICR Derived Mouse Strains for Diabetes Research
The Jackson Laboratory, Bar Harbor, ME. April 23rd, 1999
2. ALR/Lt Islets Are Remarkably Resistant To Cytokine and Autoimmune Attack
4th Immunology of Diabetes Society, November 15th,1999
2000
1. Why Can’t CTS Get an Invitation to the Thymocyte Debutante Ball?
The Jackson Laboratory, Bar Harbor, ME. February 4th, 2000
2. Is it Fate? Can Beta Cells Control Their Own Destiny In Autoimmune Diabetes?
The Jackson Labroatory, Bar Harbor, ME. April, 28th, 2000
3. Does the ß cell play a part in autoimmune diabetes or is it the corpse at a funeral?
Corixa Corporation, Palo Alto, CA. May 10, 2000
4. CTS/Shi mice: T-lymphocytopenia due to a lineage specific defect intrinsic to T cell precursors halting emigration of mature thymocytes
American Association of Immunologists Annual Meeting, Seattle, WA. May 15, 2000
5. Genetic Resistance to IDDM: A Role for ß-Cell Expressed Resistance Determinants
American Diabetes Association Scientific Sessions, June 5th, 2000
6. Does the ß cell play a part in autoimmune diabetes or is it the corpse at a funeral?
Children’s Hospital of Pittsburgh, Pittsburgh, PA. August 29, 2000
7. Free Radical Scavenging Potential in New Mouse Models of Diabetes Susceptibility and Resistance
Roche Symposium for Animals Models of NIDDM, September 19th, 2000
8. Dissipation is a Good Thing! Genetic Similarities of IDDM Resistance & Free Radical Dissipation in ALR/Lt Mice
The Jackson Laboratory, Bar Harbor, ME. December 12th, 2000
2001
1. Heightened Free Radical Dissipation Ability in a Diabetes-Resistant Mouse Strain
Biochemistry Department, University of Maine, Orono, ME. February 2, 2001.
2. The Alloxan Susceptible Mouse Strain: A New Model for the Study of T2DM
The Jackson Laboratory Post-Doctoral Symposium, March 13, 2001
3. Can Anti-oxidants Dissipate Autoimmune Diabetes? Genetic Similarities of IDDM Resistance & Free Radical Dissipation in ALR/Lt Mice
Molecular Genetics and Biochemistry Department, University of Pittsburgh Medical Center, April 22, 2001
4. Genetic Similarities of Free Radical Dissipation and IDDM Resistance in ALR/Lt Mice.
American Diabetes Association Scientific Sessions, June 19, 2001
5. New Mouse Model to Study Islet Transplantation in Insulin Dependent Diabetes Mellitus
Cell Transplant Society, 10th Congress, Keystone, CO. October 17th, 2001
6. Animal Models for the Study of Autoimmune Diabetes and Islet Transplantation
Children’s Hospital of Pittsburgh, Pittsburgh, PA. December 12, 2001
2002
1. Genetic Control of Thymocyte Emigration
Children’s Hospital of Pittsburgh, Pittsburgh, PA. February 19, 2002
2. Dietary Components Can Regulate the Penetrance of Autoimmune Diabetes Susceptibility
University of Pittsburgh School of Medicine, University Wide Endocrine Conference, March 28, 2002
3. What Controls End Stage T cell Development? Genetic Analysis of Peripherial T cell Deficiency in the CTS Mouse Strain.
Rocky Mountain Labs, Hamilton, MT, August 1st, 2002
4. Mechanisms Underlying Resistance Of ALR Islets To Cytokine Destruction
Immunology of Diabetes Society, Copper Mountain, CO. September 22, 2002
5. Reduced Thymic DC Expression of Islet Cell Antigen 69 Contributes to Loss of Self Tolerance
Immunology of Diabetes Society, Copper Mountain, CO. September 23, 2002
6. Congenic Analysis of H2gx-Linked T1D-Protection
Immunology of Diabetes Society, Copper Mountain, CO. September 24, 2002
7. Thymic Education: What Governs the Change from Thymocyte to T cell?
University of Pittsburgh, School of Medicine Immunology Department, October 31st, 2002
8. Maternal Influence on Resistance to Alloxan-Induced Diabetes
Children’s Hospital of Pittsburgh Diabetes Institute Seminar, Pittsburgh, PA. November 18th, 2002
2003
1. Enemies at the Gate: Genetic Resistance at the Pancreatic Islet level in Autoimmune Diabetes
Children’s Hospital of Pittsburgh Molecular Medicine Research Seminar, January 9th, 2003
2. Lack of Free Radical Scavenging Potential is linked to Diabetes Susceptibility
International Group on Insulin Secretion, March 18th, 2003
3. Disarming the Immune System, Subversive Propaganda, or Molecular Shielding: How do ALR Pancreatic Islets Avoid Autoimmune Destruction?
University of Massachusetts Medical Center, Worchester, MA. April 28th, 2003
4. Debutantes Need the Right Genetics: A locus that Controls Thymocyte Emigration
Merck and Company, Rahway, NJ. May 21st, 2003
5. Association of Monocyte Free Radical Production and Autoimmune Diabetes
Children’s Hospital of Pittsburgh Diabetes Institute Seminar, Pittsburgh, PA. May 21st, 2003
6. Novel Variant of mt-Nd2 Provides Protection Against Autoimmune Diabetes
Children’s Hospital of Pittsburgh Diabetes Institute Seminar, Pittsburgh, PA. June 1st, 2003
7. Reduced Thymic DC Expression of Islet Cell Antigen 69 Contributes to Loss of Self Tolerance
American Diabetes Association Scientific Sessions, New Orleans, LA, June 11th, 2003
8. ALS/Lt: A New Mouse Model of Diabetes Susceptibility Associated with Low Free Radical Scavenging Potential
Lessons From Animal Models of Diabetes, 9th Congress, Bar harbor, ME. June 15th, 2003
2004
1. Beta Cell Murder or Suicide: Does Autoimmunity Kill beta cells by Necrotic or Apoptotic Mechanisms in T1D
Children’s Hospital of Pittsburgh Diabetes Institute Seminar, Pittsburgh, PA. march 16th, 2004
2. Failure of NF-kB Activity in ALR Islets and Resistance to Autoimmunity
St. Louis University Biochemistry Department, St. Louis, MO, April 21st, 2004
3. A Steel Curtain for Beta Cells. Improved Defenses inhibit Autoimmune Killing of ALR Islets.
University of Pittsburgh, School of Medicine Immunology Department, May 24th, 2004
4. Contribution of the Mitochondrial Genome to Resistance Against both Chemically-Induced and Autoimmune Diabetes
American Diabetes Association Scientific Sessions, Orlando, FL. June 5th, 2004
5. What Failure Makes the Beta Cell Fail in Type 1 Diabetes? Failure in Self Defense.
American Diabetes Association Scientific Sessions, Orlando, FL. June 5th, 2004
6. Mitochondrial Sequence Variation Provides Protection from Oxidative Stress Induced Mitochondrial Dysfunction
American Diabetes Association Scientific Sessions, Orlando, FL. June 8th, 2004
7. A Single Nucleotide Polymorphism in the Mitochondrial Gene for NADPH Dehydrogenase Subunit 2 Contributes Resistance to Autoimmune Diabetes
United Mitochondrial Disease Foundation Annual Meeting, Pittsburgh, PA. August 6th, 2004
8. Association of Diabetes with Genetic Variation in the Mitochondrial Genome in Mice and Man
University of Pittsburgh Medical Center, University Wide Clinical Endocrinology Conference October 1st, 2004
2005
1. Genetics of T1D in Animal Models: 20 Years Later
Children’s Hospital of Pittsburgh, Diabetes Institute Seminar Series, February 16th, 2005
2. Novel mt-Nd2 Variant Encoded by the ALR/Lt Mouse Strain Provides Resistance to Free Radical-Induced Mitochondrial Dysfunction
International Group on Insulin Secretion. Nice, France. March 10th, 2005
3. Genetics of resistance to immune mediated beta-cell destruction.
Juvenile Diabetes Research Foundation Fellows Conference. Chantilly, VA, March 24th, 2005
4. Animal Models for the Study of Diabetes
Pediatric Endocrinology Fellows Conference. Pittsburgh, PA. May 5th, 2005.
5. Mutant Cat2 Protects ALR/LtJ Mouse Islets from Cytokine-Induced Beta Cell Destruction. American Diabetes Association Scientific Sessions, San Diego, CA. June 13th, 2005
6. Islet Insubordination: ALR/LtJ Genes Bestow a Failure to Comply with Autoimmune Stimuli
The Jackson Laboratory, November 10th, 2005
7. Development of Diabetes Complications in diabetic C57BL/6-Ins2Akita Mice
The Jackson Laboratory, November 11th, 2005
2006
1. New Insights into Thymocyte Emigration.
Albert Einstein College of Medicine Research Seminar Series, April 3, 2006
2. Islet Insubordination: ALR/LtJ Genes Bestow a Failure to Comply with Autoimmune Stimuli
Children’s Hospital of Pittsburgh Molecular Medicine Research Seminar, June 27th, 2006
3. Positional Cloning of a Locus Controls Thymocyte Emigration
University of Pittsburgh, School of Medicine Immunology Department, July 6th, 2006
4. A Steel Curtain for Beta Cells. Improved Defenses Inhibit Autoimmune Killing of ALR Islets.
University of Michigan, Department of Medicine, July 12th, 2006
5. Global Resistance to Inflammation Results in Resistance to Both Type 1 and Type 2 Diabetes.
University of Pittsburgh, School of Medicine, Metabolism Interest Group, August 23rd, 2006
6. Resistance to Autoimmune Diabetes at the Beta Cell Level: Tales from the ALR Mouse.
University of Florida, Department of Pathology, November 15, 2006
7. Toxin Resistance Yields Clues for Resistance to Autoimmune Diabetes.
University of Pittsburgh, Department of Environmental and Occupational Health, December 7, 2006.
2007
1. Nuclear-Mitochondrial Interactions Affect Electron Transport Chain ROS production.
Children’s Hospital of Pittsburgh, Diabetes Institute Seminar Series, Pittsburgh, PA , February 16th, 2005
2. Solute Carrier Family 7 Member 2 (Slc7a2) is critical for Arginine-Stimulated Insulin Release. International Group on Insulin Secretion. Nice, France. March 10th, 2007
3. Genetics of Mitochondrial Contribution to Beta Cell Susceptibility to Autoimmune-Mediated Destruction. American Diabetes Association Annual Scientific Sessions, Chicago, IL. June 24, 2007
4. Benign Symbiotes or Rebellious Subjugates: Novel Roles for Proteins Encoded by the Mitochondrial Genome. Symposium for the Use of Animal Models for Understanding the Pathogenesis of Diabetes, Boston, MA. July 26, 2007
5. Inbred strain variations in glucose tolerance and resistance to metabolic stress. Discovery Strategies Conference: Modeling Human Metabolic Syndrome and Type 2 Diabetes in Rodents, Bar Harbor, ME. August 6, 2007
2008
1. Role of mitochondria in autoimmune-mediated destruction of beta cells.
8th Annual Rachmiel Levine Symposium, Translational Research in Type 1 Diabetes: Beyond Insulin and the Edmonton Protocol, Newport Beach, CA. January 13, 2008
2. New models to test old hypotheses in mitochondrial biology
University of Florida, Mitochondrial Interest Group, June 11, 2009
3. Genetic variation in the mitochondrial genome & diabetes
Department of Food Science and Human Nutrition, University of Florida, October 9, 2009
4. mt-Nd2 and Resistance to Autoimmune Diabetes
National Institutes of Health, NIDDK, November 17, 2009
2009
1. Prevention of T1D by blocking beta cell death: Lessons from the ALR mouse.
Department of Pathology, Immunology, and Laboratory Medicine, work in progress seminar series, January 5, 2009.
2. Susceptibility to spontaneous autoimmune and free radical-mediated diabetes is controlled by interactions of the nuclear & mitochondrial genomes
The Burnham Institute, Orlando, FL. February 13, 2009
3. Prevention of Beta Cell Destruction Prior to and After Onset of Type 1 Diabetes
Grand Rounds, Department of Pathology, Immunology, and Laboratory Medicine, University of Florida
4. Superoxide Alters the Texture of Inflammation
University of Alabama, Birmingham, AL, September 17, 2009
5. Intergenomic Interactions between the Nuclear & Mitochondrial Genomes Control Susceptibility to Diabetes
LSU Health Sciences Center, Shreveport, LA, October 8, 2009
2010
1. A Little Dissipation is a Good Thing
University of South Alabama, Mobile, AL, January 2010
2. Diabetes Research in the Swamp
The Jackson Laboratory, Bar Harbor, ME, August 16, 2010
2011
1. Dissipating Autoimmunity: Role of Reactive Oxygen Species in Adaptive Immune Effector Function
Rheumatology, work in progress seminar series, University of Florida, January 5, 2011.
2. Mitochondria, Oxidants, Beta Cells, and Diabetes
Experimental Biology, Washington, DC, April 12, 2011
3. Beta Cell Dysfunction and Type 1 Diabetes
Endocrinology Conference, University of Florida, July 19, 2011
4. Autoimmune Diabetes
HHMI Seminar Series, University of Florida, September 20, 2011
5. Personalization of Immunotherapy for Type 1 Diabetes Using Metabolic Markers
Program in Personalized & Genomic Medicine Seminar Series, University of Maryland School of Medicine, November 9, 2011
2012
1. New developments in beta cell participation in type 1 diabetes
Diabetes Care Program, Gainesville, FL, January 20, 2012
2. Wassup in type 1 diabetes research
Department of Pathology, Immunology, and Laboratory Medicine, work in progress seminar series, January 5, 2012.