Refereed Articles

1.      Mathews CE, McGraw RA, Berdanier CD.  1995.  A point mutation in the mitochondrial DNA of diabetes prone BHE/cdb rats.  FASEB J 9:1638-1642.

2.      Mathews CE, Wickwire KL, Hathcock-Rice D, Berdanier CD.  1996.  Maternal diet has little effect on the glucose tolerance and age changes in enzyme activity in male progeny of gestationally diabetic rats.  Int J Diabetes 4:17-27.

3.      Mathews CE and Berdanier CD.  1997.  A gene screen for mitochondrial diabetes mellitus in BHE/Cdb rats.  Exp Clin Endocrinol Diabetes 105:86-87.

4.      Jia T, Wickwire KL, Mathews CE, Berdanier.  1998.  Neither the cholesterol nor arginine content of whole egg explains its beneficial effect on glucose homeostasis in BHE//Cdb rats.  J Nutr Biochem 9:170-177.

5.      Mathews CE and Berdanier CD.  1998.  Noninsulin-dependent diabetes mellitus as a mitochondrial genomic disease.  Proc Soc Exp Biol Med 219:97-108.

6.      Ebert DH, Bischof LJ, Steeper RS, Chapman SC, Svitek CA, Goldman JK, Mathews CE, Leiter EH, Hutton JC, O’Brien RM.  1999.  Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene.  Diabetes 48:543-551.

7.      Graser RT, Mathews CE, Leiter EH, Serreze DV.  1999.  MHC characterization of ALR and ALS mice: Respective similarities to the NOD and NON strains.  Immunogenetics 49:722-726.

8.      Mathews CE and Leiter EH.  1999.  Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait.  Diabetes 48:2189-2196.

9.      Mathews CE and Leiter EH.  1999.  Constitutive differences in antioxidant defense status distinguish alloxan-resistant and alloxan-susceptible mice.  Free Radic Biol Med 27:449-455.

10.    Mathews CE, McGraw RA, Dean R, Berdanier CD.  1999.  Inheritance of a mitochondrial DNA defect and impaired glucose tolerance in BHE/cdb rats.  Diabetologia 42:35-40.

11.    Mathews CE, Graser RT, Serreze DV, Leiter EH.  2000.  Reevaluation of the major histocompatibility complex genes of the NOD-progenitor CTS/Shi strain.  Diabetes 49:131-134.

12.    Mathews CE, Wickwire K, Flatt WP, Berdanier CD.  2000.  Attenuation of circadian rhythms of food intake and respiration in aging diabetes-prone BHE/Cdb rats.  Am J Physiol.  279:R230-R238.

13.    Mathews CE, Graser RT, Savinov AY, Serreze DV, Leiter EH.  2001.  Unusual resistance of ALR/Lt beta cells to autoimmune destruction:  Role for beta cell expressed resistance determinants.  Proc Natl Acad Sci USA.  98:235-240.

14.    Berdanier CD, Everts HB, Hermoyian C, Mathews CE.  2001.  Role of vitamin A in mitochondrial gene expression.  Diabetes Res Clin Pract 54:11-27.

15.    Mathews CE, Dunn BD, Hannigan MO, Huang C-K, Leiter EH.  2002.  Genetic Control Of Neutrophil Superoxide Burst Activity In Diabetes Resistant ALR/Lt Mice.  Free Radical Biol. Med. 32:744-751.

16.    Mathews CE, Langley SH, Leiter EH.  2002.  New Mouse Model to Study Islet Transplantation in Insulin Dependent Diabetes Mellitus.  Transplantation 73:1333-1336.

17.    Mathews CE, Pietropaolo SL, Pietropaolo M.  2003.  Reduced Thymic DC Expression of Islet Cell Antigen 69 Contributes to Loss of Self Tolerance.  Ann NY Acad Sci.  1003:412-417.

18.    Mathews CE, Graser RT, Bagley RJ, Caldwell JW, Li R, Churchill GA, Serreze DV, Leiter EH.  2003.  Genetic Analysis of Resistance to Type 1 Diabetes in ALR/Lt Mice, a NOD-related Strain with Defenses Against Autoimmune-mediated Diabetogenic Stress.  Immunogenetics.  55:491-496.

19.    Mathews CE, Bagley RJ, Leiter EH.  2004  ALS/Lt:  A New Type 2 Diabetes Mouse Model Associated with Low Free Radical Scavenging Potential.  Diabetes.  53:125-129.

20.    Milton MJ, Poulin M, Mathews C, Piganelli JD.  2004  Generation, maintenance, and adoptive transfer of diabetogenic T-cell lines/clones from the nonobese diabetic mouse.  Methods Mol Med. 102:213-226.

21.    Mathews CE, Leiter EH, Spirina O, Bykhovskaya Y, Ringquist S, Gusdon AM, Fischel-Ghodsian N.  2005  mt-Nd2 Allele of the ALR/Lt Mouse Confers Resistance Against both Chemically-Induced and Autoimmune Diabetes.  Diabetologia  48:261-267.

22.    Kitiphongspattana K, Mathews CE, Leiter EH, Gaskins HR.  2005  Proteasome inactivation alters glucose-stimulated insulin secretion and turnover in pancreatic ß cells.  J Biol Chem.  280:15727-15734.

23.    Pomerleau DP, BagleyRJ, HollTM, Serreze DV, Mathews CE, Leiter EH.  2005  MHC-linked diabetes susceptibility in NOD/Lt mice: subcongenic analysis localizes a component of Idd16 at the H2-D end of the diabetogenic H2g7 complex.  Diabetes  54:1603-1606.

24.    Mathews CE, Suarez-Pinzon WL, Baust JJ, Strynadka K, Leiter EH, Rabinovitch A.  2005  Mechanisms Underlying Resistance of Pancreatic Islets from ALR/Lt Mice To Cytokine-Induced Destruction.  J Immunol.  175:1248-1256.

25.    Chang Y-G, Yap S, Ge X, Piganelli J, Bertera S, Giannokakis N, Mathews CE, Prud’homme G and Trucco M.  2005.  DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice.  Gene. Ther.  12:1679-1685.

26.    Takaki T, Marron MP, Mathews CE, Guttmann ST, Bottino R, Trucco M, DiLorenzo TP, Serreze DV.  HLA-A*0201-restricted T-cells Contributing to Type 1 Diabetes in “Humanized” Mice are Cytotoxic to Human Pancreatic ß Cells, and Identify Autoantigens with Potential Clinical Relevance.  2006  J Immunol.  176:3257-3265.

27.    Ge X, Piganelli JD, Tse HM, Bertera S, Mathews CE, Trucco M, Wen L, Rudert WA.  2006  Co-expression of HLA-DR4 Alleles Diminishes HLA-DQ8-restricted CD4 T Cell Responses: A Possible Mechanism For the DR4-mediated Modulation Effect To the Type 1 Diabetes Susceptibility.  Diabetes.  55:3455-3462

28.    Sen P, Wallet M, Yi Z, Huang Y, Henderson M, Mathews CE, Earp HS, Matsushima G, Baldwin Jr. AS and Tisch R.  2007  Apoptotic cells induce MerTK-dependent blockade of NF-κB activation in dendritic cells.  Blood.  109:653-660

29.    Gusdon AM, Votyakova TV, Reynolds IJ, Mathews CE.  2007  Nuclear-Mitochondrial Interaction Involving mt-Nd2 Leads to Increased Mitochondrial Reactive Oxygen Species Production.  J Biol Chem.  282:5171-517

30.    WalletMA, Sen P, Flores R, Yi Z, Huang Y, Mathews CE, EarpHS, Matsushima G, Wang B, Tisch R.  2008  MerTK is required for apoptotic cell-induced T cell tolerance.  J Exp Med.  205:219-232.

31.    Gusdon AM, Votyakova TV, Mathews CE.  2008  mt-Nd2a Suppresses Mitochondrial Reactive Oxygen Species Production.  J Biol Chem. 283:10690-10697.

32.    Chen J, Gusdon AM, Thayer TC, Mathews CE.  2008  Role of increased ROS dissipation in prevention of T1D: Lessons from the ALR mouse. Ann N Y Acad Sci.  1150:157-166

33.    Chen J, Lu Y, Lee C-H, Li R, Leiter EH, Mathews CE.  2008  Comparative Genetics of Spontaneous Autoimmune versus Chemically-Induced Diabetes in Mice.  Free Radic Biol Med. 45:1263-1270

34.    Wallet MA, Flores RR, Wang Y, Yi Z, Kroger CJ, Mathews CE, Earp HS, Matsushima1 G, Wang B, Tisch R.  2009 MerTK regulates thymic selection of autoreactive T cells.  Proc Natl Acad Sci USA. 106:4810-4815.

35.    Gusdon AM, Chen J, Votyakova TV, Mathews CE.  2009  Quantification, Localization, and Tissue Specificities of Mitochondrial Reactive Oxygen Species Production.  Methods Enzymol. 456:439-457.

36.    Ben-Yehudah A, White C, Navara CS, Castro CA, Ize-Ludlow D, Shaffer B, Sukhwani M, Mathews CE, Chaillet JR, Witchel SF.  Evaluating protocols for embryonic stem cell differentiation into insulin secreting-cells using Insulin II-GFP as a specific and non-invasive reporter. Cloning and Stem Cells. 112;245-257

37.    Park H-J, Zhang Y, Chuang Du, Welzig CM, Madias C, Naggar I, Georgescu SP, Wang B, Aronovitz MJ, Blaustein RO, Karas RH, Liao R, Mathews CE, Galper JB.  A New Molecular Mechanism For Diabetic Autonomic Neuropathy: Srebp-1 Regulation Of Parasymapthetic Signaling In The Heart.  Circulation Research.  105:287-294

38.    Parker MP, Xue S, Alexander JJ, Wasserfall CH, Campbell-Thompson ML, Battaglia M, Gregori S, Mathews CE, Song S, Troutt M, Eisenbeis S, Williams J, Schatz DA, Haller MJ, Atkinson MA Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in NOD mice.  Diabetes.  2009, 58:2277-2284

39.    Tse HM, Thayer TC, Steele C, Cuda CM, Morel L, Piganelli JD, Mathews CE.  NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.  J Immunol. 2010, 185:5247-5258.  PMID: 20881184

40.    Delano MJ, Thayer T, Gabrilovich S, Kelly-Scumpia KM, Winfield RD, Scumpia PO, Cuenca AG, Warner E, Wallet SM, Wallet MA, O’Malley KA, Ramphal R, Clare-Salzer M, Efron PA, Mathews CE, Moldawer LL.  Sepsis Induces Early Alterations in Innate Immunity That Impact Mortality to Secondary Infection.  J Immunol.  186:195-202.  PMID: 21106855

41.    Chen J, Gusdon AM, Piganelli J, Leiter EH, Mathews CEmt-Nd2a modifies resistance against autoimmune Type 1 diabetes in NOD mice at the level of the pancreatic beta cell.  Diabetes.  2011, 60:355-359.  PMID: 20980458

42.    Cuenca AG, Wynn JL, Kelly-Scumpia KM, Scumpia PO, Vila L, Delano MJ, Mathews CE, Wallet SM, Reeves WH, Behrns KE, Nacionales DC, Efron PA, Kunkel SL, Moldawer LL.  Critical role for CXCL10 (IP-10)/CXCR3 signaling in the murine neonatal response to sepsis.  Infect Immun. 2011 Jul;79(7):2746-54.  PMID: 21518789

43.    Chen J, Grieshaber S, Mathews CE.  Methods to assess beta cell death mediated by cytotoxic T lymphocytes.  J Vis Exp. 2011 Jun 16;(52). pii: 2724. doi: 10.3791/2724.  PMID: 21712795

44.    Delano MJ, Kelly-Scumpia KM, Winfield RD, Scumpia PO, Cuenca AG, Harrington PB, O’Malley KA, Warner E, Gabrilovich S, Mathews CE, Laface D, Heyworth PD, Ramphal R, Strieter RM, Moldawer LL.  Neutrophil Mobilization from the Bone Marrow During Polymicrobial Sepsis Is Dependent On CXCL12 Signaling.  J Immunol. 2011 Jul 15;187(2):911-918.  PMID: 21690321

45.    Lightfoot YL, Chen J, Mathews CE.  Role of the Mitochondria in Immune-Mediated Apoptotic Death of Human BetaCells.  PLoS One. 2011;6(6):e20617.  PMID: 21738580

46.    Ize-Ludlow D, Lightfoot YL, Parker MJ, Xue S, Wasserfall CH, Haller MJ, Schatz DA, Becker DJ, Atkinson MA, Mathews CE.  Progressive Erosion of Beta Cell Function Precedes the Onset of Hyperglycemia in the NOD Mouse Model of Type 1 Diabetes.  Diabetes. 2011.  PMID: 21659497

47.    Thayer TC, Delano MJ, Liu C, Chen J, Padgett L, Annamali M, Piganelli JD, Tse HM, Moldawer LL, Mathews CE.  Superoxide Production by Macrophages and T cells is Critical for the Induction of Autoreactivity and Type 1 Diabetes.  Diabetes.  Diabetes. 2011 Aug;60(8):2144-51.  PMID:  21715554

48.    Chen J, Gusdon AM, Mathews CE.  Role of mt-Nd2 in Type 1 Diabetes.  Diabetes Metab Res Rev. 2011 Nov;27(8):849-53.  PMID: 22069272

49.    Glushakova LG, Judge S, Cruz A, Pourang D, Mathews CE, Stacpoole PW.  Biochemical consequences of pyruvate dehydrogenase complex deficiency.  Mol Genet Metab. 2011 Nov;104(3):255-60. PMID:  21846590

50.    Wang W, Guo Y, Xu M, Huang H, Novikova L, Larade K, Jiang Z, Thayer TC, Frontera JR, Aires D, Ding H, Turk J, Mathews CE, Bunn HF, Stehno-Bittel L, Zhu H.  Development of Diabetes in Ncb5or-Null Mice is Associated with Manifestations of Endoplasmic Reticulum and Oxidative Stress in Beta Cells.  Biochim Biophys Acta. 2011 Nov;1812(11):1532-1541. PMID:  21839170

51.    Xu Y, Lee PY, Li Y, Liu C, Zhuang H, Han S, Nacionales DC, Weinstein J, Mathews CE, Moldawer LL, Li SW, Satoh M, Yang LJ, Reeves WH.  Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus.  J Immunol. 2012 Apr 15;188(8):4113-4121.  PMID:  22422888

52.    Lightfoot YL, Chen J, Mathews CE.  Oxidative Stress and Beta Cell Dysfunction.  Methods Mol Biol. 2012;900:347-62.  PMID: 22933078

53.    Lightfoot YL, Chen J, Mathews CE.  Immune-mediated β-cell death in type 1 diabetes.  Eur J Clin Invest.  2012;42(11):1244-1251.  PMID:  22924552


54.    Aaron M. Gusdon, Jenelle Fernandez, Jing Chen, and Clayton E. Mathews.  Respiration and reactive oxygen species production distinguish mitochondria from brain and liver.  Lab Invest.  In Revision

55.    Diego Ize-Ludlow, Lesley G. Ellies, Yaima Lightfoot, Lisa M. Gallo, Rita Bottino, Alberto Riva, and Clayton E. Mathews.  Solute Carrier Family 7a Member 2 (Slc7a2) Is Essential For Arginine Induced Insulin Release Yet Dispensable For Proinflammatory Cytokine-Induced Nitric Oxide Production In Pancreatic Islets.  J Biol. Chem.  In Revision.

56.    Xue S, Wasserfall C, Myhr C, Campbell-Thompson M, Mathews CE, Burn P, Rabinovitch A, Savinov A, Schatz D, Haller M, Atkinson M.  Combination Therapy Reverses Hyperglycemia in NOD Mice with Established Type 1 Diabetes.  J Clin Invest.  Submitted

57.    Li J-W, Cassidy RJ, Liu C, Perry D, Brusko TM, Mathews CE, Chen J.  Patients and Individuals At-risk for Developing Type 1 Diabetes exhibit Peripheral T Cell Mitochondrial Inner Membrane Hyperpolarization.  Diabetes Care.  Submitted